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Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

30.03.2026 03:37

Researchers showed that chronic colitis leaves a long-lasting epigenetic memory in colonic stem cells, persisting for more than 100 days after recovery in mice. This memory is marked by durable AP-1-l...

APOE4 alters brain immunity and cognition differently in females and males

30.03.2026 03:05

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vuln...

Intensive LDL cholesterol-lowering shows major benefits for heart disease patients

29.03.2026 01:57

Using cholesterol-lowering medications more intensively to achieve a more aggressive target for low-density lipoprotein cholesterol (LDL-C) reduced the rate of major cardiovascular events by one-third...

Evolocumab reduces cardiac events in high-risk diabetic patients

29.03.2026 01:42

The cholesterol-lowering therapy evolocumab reduced the risk of major adverse cardiac events by nearly one-third among patients who had no known significant atherosclerosis and had diabetes, according...

Home-delivered DASH diet improves blood pressure and cholesterol outcomes

29.03.2026 01:35

Black adults with high blood pressure who received dietitian counseling and home deliveries of groceries aligned with the DASH diet—meaning high in fruits, vegetables, whole grains, low-fat dairy, n...

Investigational drug lowers angiotensinogen but shows unclear blood pressure benefits

29.03.2026 01:18

The investigational drug tonlamarsen—which is designed to lower blood pressure by reducing the production of angiotensinogen, a protein that turns into the hormone that regulates blood pressure—ca...

Intensive cholesterol‑lowering therapy reduces first major cardiac event in high‑risk patients with diabetes

29.03.2026 01:03

Mass General Brigham researchers found that the intensive cholesterol‑lowering therapy evolocumab reduced the risk of a first major cardiovascular event in high‑risk patients who did not have know...

Hypercortisolism found in many patients with resistant hypertension

28.03.2026 18:15

The MOMENTUM study found 27 percent of patients with resistant hypertension have hypercortisolism. This is a significant finding, demonstrating that hypercortisolism is more common in these patients t...

Microaxial flow pump fails to reduce heart damage in STEMI trial

28.03.2026 16:52

Using a microaxial flow pump prior to and during cardiac stenting procedures for patients with severe heart attacks who don't have cardiogenic shock does not significantly reduce heart damage.

Catheter-based approach improves prognosis in pulmonary embolism patients

28.03.2026 16:44

Patients who had low doses of clot-buster drugs delivered directly to the site of a pulmonary embolism (PE) via a catheter using ultrasound to enhance their effect had significantly better outcomes th...